Philadelphia University + Thomas Jefferson University

Hajnoczky, Gyorgy

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Gyorgy Hajnoczky, MD, PhD

Gyorgy Hajnoczky, MD, PhD

Contact Dr. Hajnoczky

1020 Locust Street
527 Alumni Hall
Philadelphia, PA 19107

(215) 503-1427

Medical School

MD, Semmelweis University, Budapest - 1987
PhD, Semmelweis University, Budapest - 1987
National Academy of Sciences, Hungary - 1995

University Appointment

Raphael Rubin, MD Professor, Department of Pathology, Anatomy & Cell Biology

Research and Clinical Interests

Intracellular calcium signaling; inositol trisphosphate-linked hormones; organization of calcium mobilization from endoplasmic/sarcoplasmic reticulum; mitochondrial calcium signaling; calcium-dependent control over life and death of cells; fluorometric, fluorescence microscope imaging and electrophysiological approaches.

Signaling, calcium, ER, mitochondria, metabolism, apoptosis, imaging

Publications

Most Recent Peer-Reviewed Publications

  1. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
  2. ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak
  3. Mitochondrial Nanotunnels
  4. Recessive mutations in MSTO1 cause mitochondrial dynamics impairment, leading to myopathy and ataxia
  5. MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans
  6. Intracellular Ca2+Sensing: Its Role in Calcium Homeostasis and Signaling
  7. Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU
  8. Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity
  9. Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges
  10. Natural and induced mitochondrial phosphate carrier loss: Differential dependence of mitochondrial metabolism and dynamics and cell survival on the extent of depletion
  11. VDAC2-specific cellular functions and the underlying structure
  12. Subcellular ROS imaging methods: Relevance for the study of calcium signaling
  13. Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface
  14. MICU1 regulation of mitochondrial Ca 2+ uptake dictates survival and tissue regeneration
  15. Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis
  16. The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease
  17. Trans-mitochondrial coordination of cristae at regulated membrane junctions
  18. Mitochondrial ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity
  19. Erratum: MCUR1 is an essential component of mitochondrial Ca2+uptake that regulates cellular metabolism (Nat. Cell Biol. 14, 2012 (1336-1343))
  20. Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015