Arie Horowitz, DSc
Philadelphia, PA 19107
(215) 955-9170 fax
Research & Clinical Interests
My laboratory conducts basic research in vascular biology. Our objective is to understand how blood vessels regulate the permeability of their walls. Specifically, we study how the junctions between adjacent endothelial cells on the lumen of vessels are maintained, and how they respond to external stimuli, such as vascular endothelial growth factor. We pursue these questions by probing intracellular signaling pathways and protein complexes that determine the behavior of the junctions. We use cell culture and genetically modified mouse models in combination with advanced optical imaging techniques.
In addition to my membership in the Cardeza Center, I am an adjunct faculty in Cancer Biology, and a member of the Genetics, Genomics and Cancer Biology graduate program, and of the Sidney Kimmel Cancer Center in the Extracellular Matrix and Metastasis program.
Most Recent Peer-Reviewed Publications
- Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease
- Analysis of retinoic acid-induced neural differentiation of mouse embryonic stem cells in two and three-dimensional embryoid bodies
- Letter by Horowitz Regarding Article, "protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability"
- The versatility of RhoA activities in neural differentiation
- RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms
- The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover
- VEGF and angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx
- Stimulus-dependent phosphorylation of profilin-1 in angiogenesis
- Regulation of VEGF signaling by membrane traffic
- Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis
- Erratum: Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways (Circulation Research (2008) 103 (e71-e79))
- Imaging of growth factor-augmented angiogenesis after myocardial infarction: glimmers of a spatiotemporal pattern?
- Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion
- Branching morphogenesis
- The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells
- Branching morphogenesis
- Syx, a rhoA guanine exchange factor, is essential for angiogenesis in vivo
- Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways
- Directional cues in angiogenesis
- Erratum: Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles (Proceedings of the National Academy of Sciences of the United States of America (August 22, 2006) 103, 34 (12735-12740) DOI: 10.1073/pnas.0605317103)