James H. Keen, PhD

Contact Dr. Keen

233 S. 10th Street
915 BLSB
Philadelphia, PA 19107

(215) 503-4624
(215) 503-0622 fax

Most Recent Peer-reviewed Publications

  1. Exosome-mediated transfer of αvβ3 integrin from tumorigenic to nontumorigenic cells promotes a migratory phenotype
  2. Integrins influence the size and dynamics of signaling microclusters in a Pyk2-dependent manner
  3. Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration
  4. Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog
  5. Arf6 regulation of Gyrating-Clathrin
  6. GGA3 functions as a switch to promote met receptor recycling, essential for sustained ERK and cell migration
  7. Development and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processes
  8. Gyrating clathrin: Highly dynamic clathrin structures involved in rapid receptor recycling
  9. Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2
  10. Phosphoinositide 3-kinase C2α links clathrin to microtubule-dependent movement
  11. Dynamics of membrane clathrin-coated structures during cytokinesis
  12. Individual phosphoinositide 3-kinase C2α domain activities independently regulate clathrin function
  13. Membrane targeting of endocytic adaptors: Cargo and lipid do it together
  14. Major histocompatibility complex class I-intercellular adhesion molecule-1 association on the surface of target cells: Implications for antigen presentation to cytotoxic T lymphocytes
  15. Signaling Down the Endocytic Pathway
  16. The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4
  17. A glimpse of coated vesicle creation? Well almost!
  18. G protein-coupled receptor/arrestin3 modulation of the endocytic machinery
  19. The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro
  20. The class II phosphoinositide 3-kinase C2α is activated by clathrin and regulates clathrin-mediated membrane trafficking