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Maurizio Pacifici, PhD

Contact Dr. Pacifici

Children's Hospital of Philadelphia
3400 Civic Center Boulevard
Philadelphia, PA 19104

(215) 955-7352
(215) 955-9159 fax

Most Recent Peer-reviewed Publications

  1. Acquired and congenital forms of heterotopic ossification: new pathogenic insights and therapeutic opportunities
  2. Retinoid roles and action in skeletal development and growth provide the rationale for an ongoing heterotopic ossification prevention trial
  3. Roles of Ihh signaling in chondroprogenitor function in postnatal condylar cartilage
  4. Intervertebral Disc Degeneration in a Percutaneous Mouse Tail Injury Model
  5. Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference
  6. The pathogenic roles of heparan sulfate deficiency in hereditary multiple exostoses
  7. Hereditary Multiple Exostoses: New Insights into Pathogenesis, Clinical Complications, and Potential Treatments
  8. Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs
  9. Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation
  10. Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice
  11. Epiprofin Regulates Enamel Formation and Tooth Morphogenesis by Controlling Epithelial-Mesenchymal Interactions During Tooth Development
  12. Assessing the general population frequency of rare coding variants in the EXT1 and EXT2 genes previously implicated in hereditary multiple exostoses
  13. Effectiveness and mode of action of a combination therapy for heterotopic ossification with a retinoid agonist and an anti-inflammatory agent
  14. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1R206HFibrodysplasia Ossificans Progressiva (FOP) Mutation
  15. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model
  16. HhAntag, a Hedgehog Signaling Antagonist, Suppresses Chondrogenesis and Modulates Canonical and Non-Canonical BMP Signaling
  17. Osteophyte formation and matrix mineralization in a TMJ osteoarthritis mouse model are associated with ectopic hedgehog signaling
  18. Excess BMP Signaling in Heterotopic Cartilage Forming in Prg4 -null TMJ Discs
  19. Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders
  20. Delayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs