Our lab focus is in the fields of stem cell biology and neuroprotection with an emphasis on Parkinson’s disease (PD) and stroke models. Human induced pluripotent stem cells (iPSCs, left), with their potential to generate autologous patient-derived cells (such as, dopamine neurons in green, right) hold great promise for the study and treatment of a host of devastating diseases, including PD. Endogenous stem cells present in the adult brain are likewise important in repair particularly after acute injury like stroke. Our lab has concentrated on the molecular and cellular changes in the blood-brain-barrier that ultimately lead to regulation of stem cell proliferation and neuronal differentiation after stroke. We also have focused our studies on the discovery of novel factors capable of protecting neurons at risk for dying during progressive disease (PD) or after injury (stroke).
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