Philadelphia University + Thomas Jefferson University

Simone Laboratory

Description

lab

Dr. Simone’s laboratory has contributed significantly to understanding mechanisms that underlie cytotoxic treatment resistance and tumor progression by studying the microRNA drivers and effects of cells metabolism via dietary alterations. Her laboratory demonstrated for the first time that caloric restriction (CR) modifies change in vivo at the microRNA level (Orum et al, Cell Cycle. 2012). The Simone laboratory then explored the physiologic impact of CR and demonstrated for the first time that CR can augment radiation therapy (Saleh et al., Cell Cycle. 2013), which she then translated directly into a clinical trial using diet during radiation for early stage breast cancer patients (NCT01819233). The lab found the same improved physiologic response of the primary tumor in vivo when CR was combined with chemotherapy and this was also translated directly to a clinical trial (NCT02827370). The Simone laboratory was also the first to investigate the mechanistic role of microRNAs in the ability of CR to decrease metastatic disease burden via control of the ECM (Jin et al, Breast Cancer Res Treat. 2014 and Simone BA, Cell Cycle. 2016) which is being discussed as a NRG clinical trial concept. To further understand how diet can improve microRNA drivers of cancer progression, her microRNAs role of microRNAs in third IIT is accruing patients with endometrial, prostate and breast cancer who undergo CR before definitive oncologic surgery (NCT02983279).

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Nicole L. Simone, MD
Associate Professor

Contact Dr. Simone

111 South 11th Street
Bodine Center, Suite G-301
Philadelphia, PA 19107

(215) 955-0412