Cytomegalovirus (CMV) is herpesvirus that infects most people in the world early in life and is never cleared. Infection after birth is typically asymptomatic and the virus is well controlled in most tissues. However, infection is utero can be devastating to the developing fetus. In fact, CMV is the most common infectious cause of birth defects. The Snyder lab studies T cells responses elicited by CMV infection, particularly at barrier tissues that are sites of viral entry and shedding. In addition, we are exploring the use of CMV as a cancer therapy that can modulate the tumor microenvironment and promote productive anti-tumor responses.
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