Philadelphia University + Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Kiriakidou, Marianthi

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Marianthi Kiriakidou, MD

Marianthi Kiriakidou, MD

Contact Dr. Kiriakidou

211 South 9th Street
Suite 210
Philadelphia, PA 19107

(215) 955-2820
(215) 923-7885 fax

Medical School

Aristotle University School of Medicine, Thessaloniki, Greece


Northeastern Pennsylvania Hospitals, Wilkes-Barre, PA


University of Pennsylvania, Philadelphia, PA

Board Certification


Hospital Appointment

Thomas Jefferson University Hospital

Research & Clinical Interests

Dr. Kiriakidou joined Thomas Jefferson University in 2013 as an Associate Professor of Medicine and Director of the Jefferson Lupus Center. After graduating from Aristotele University of Thessaloniki, Greece, Dr. Kiriakidou joined the Center for Women’s Health and Reproduction at the University of Pennsylvania, where she studied mechanisms of cholesterol transfer and steroid hormone synthesis.  After completing Internal Medicine residency at Northeastern Pennsylvania Hospitals and Rheumatology fellowship at the University of Pennsylvania, she combined patient care with basic research as Assistant Professor at the University of Pennsylvania and at her current position at Thomas Jefferson University. Her research focuses on the mechanisms of gene expression regulation by microRNAs and on the role of microRNAs in the immune dysfunction in SLE. In addition to clinical care and disease-oriented basic research, Dr. Kiriakidou is establishing the Jefferson Lupus Cohort with the goal of identifying disease markers or characteristics that signify risk for organ damage in lupus.


Most Recent Peer-Reviewed Publications

  1. Two interesting cases of intracranial IgG4-related disease and discussion of therapy options
  2. MicroRNA-21 deficiency protects from lupus-like autoimmunity in the chronic graft-versus-host disease model of systemic lupus erythematosus
  3. Systemic lupus erythematosus
  4. Small molecule inhibition of RISC loading
  5. Silencing of microR6-21 in vivo ameliorates autoimmune splenomegaly in lupus mice
  6. Clarifying mammalian RISC assembly in vitro
  7. High-throughput experimental studies to identify miRNA targets directly, with special focus on the mammalian brain
  8. Expanded RNA-binding activities of mammalian Argonaute 2
  9. A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells
  10. An mRNA m7G Cap Binding-like Motif within Human Ago2 Represses Translation
  11. Detection of microRNAs and assays to monitor microRNA activities in vivo and in vitro.
  12. A combined computational-experimental approach predicts human microRNA targets
  13. The microRNA world: Small is mighty
  14. Sperm antigen 6 is the murine homologue of the Chlamydomonas reinhardtii central apparatus protein encoded by the PF16 locus
  15. The steroidogenic acute regulatory protein (StaR): A window into the complexities of intracellular cholesterol trafficking
  16. cDNA cloning and characterization of a human sperm antigen (SPAG6) with homology to the product of the Chlamydomonas PF16 locus
  17. Multiple steroidogenic factor 1 binding elements in the human steroidogenic acute regulatory protein gene 5'-flanking region are required for maximal promoter activity and cyclic AMP responsiveness
  18. Molecular insights into the regulation of steroidogenesis: From laboratory to clinic and back
  19. Structural and functional changes in mitochondria associated with trophoblast differentiation: Methods to isolate enriched preparations of syncytiotrophoblast mitochondria
  20. Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region