Sense of Smell Restoration Research at Jefferson



Jefferson Department of Otolaryngology surgeons—Drs. Edmund Pribitkin and David Rosen—are leading a study designed to help a cohort of patients experiencing significant loss in their sense of smell. Each patient will be tested before and after the study to assess the amount of olfactory sense restored. For the procedure, patients will have blood drawn and spun in a centrifuge to isolate their PRP. Patients will then have PRP injected into their nose where the olfactory cells are located. This process will be repeated three times for each patient.

Phase I

The initial phase of the Sense of Smell Restoration Project began with 30 patients, the most recent eight patients received the benefit of being completely on topical PRP. It is the largest pilot study to-date for the use of PRP in treatment of olfactory dysfunction (OD), and the first study to develop methods for topical delivery in human subjects.

Phase II

With philanthropic support, our team plans to enroll 60 new patients in Phase II Clinical testing. In this first-of-its-kind placebo controlled study for anosmia, our team will exclusively look at patients who developed long-term OD following recovery from COVID-19. Dr. Rosen believes this is the “first ever” placebo controlled study for anosmia. This will help our research team better understand patient variables, and the number of treatments required to maintain sustainable improvements in smell and taste. 


Edmund Pribitkin, MD, MBA
Chief Physician Executive, Jefferson Health
President, Jefferson Medical Group
Professor, Deptartment of Otolaryngology – Head & Neck Surgery


David Rosen, MD
Associate Professor
Thomas Jefferson University

Losing my smell and taste from COVID has been life changing. For the first time in a long time, I have hope for getting my life back to normal.

Nancy A. Damato Grateful Patient and Clinical Trial Participant

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Name: Andy Kitaeff
Position: Assistant Vice President of Development, Office of Institutional Advancement
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