Philadelphia University + Thomas Jefferson University

Yang, Hushan

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Hushan Yang, PhD

Hushan Yang, PhD

Contact Dr. Yang

834 Chestnut Street
The Franklin Building, Suite 314
Philadelphia, PA 19107

(215) 503-6521
(215) 503-9506 fax

Research & Clinical Interests

Our research integrates the increasing knowledge of biological mechanisms of cancer development with current interdisciplinary strategies to develop reliable cancer risk and prognosis prediction models. Our study utilizes genetic variation in the human genome and other biological and pathological markers as surrogates of cancer risk and treatment outcome, in order to achieve tailored prediction based on the specific profile of individual patients.

Publications

Most Recent Peer-Reviewed Publications

  1. MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation
  2. TNFα induces Ca2+influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells
  3. Multi-regional sequencing reveals intratumor heterogeneity and positive selection of somatic mtDNA mutations in hepatocellular carcinoma and colorectal cancer
  4. Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations
  5. MCU-dependent mitochondrial Ca2+inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells
  6. Polymorphisms in genes related to epithelial-mesenchymal transition and risk of non-small cell lung cancer
  7. Prognostic values of cancer associated macrophage-like cells (CAML) enumeration in metastatic breast cancer
  8. Genetic variations of mitochondrial genome modify risk and prognosis of hepatocellular carcinoma patients
  9. Cancer driver gene discovery through an integrative genomics approach in a non-parametric Bayesian framework
  10. Heparin promotes cardiac differentiation of human pluripotent stem cells in chemically defined albumin-free medium, enabling consistent manufacture of cardiomyocytes
  11. Prospective and longitudinal evaluations of telomere length of circulating DNA as a risk predictor of hepatocellular carcinoma in HBV patients
  12. Longitudinally collected CTCs and CTC-clusters and clinical outcomes of metastatic breast cancer
  13. Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis
  14. A phase I/II study of the investigational drug alisertib in combination with abiraterone and prednisone for patientswithmetastatic castration-resistant prostate cancer progressing on abiraterone
  15. Alterations of telomere length and mtDNA copy number are associated with overall survival in hepatocellular carcinoma patients treated with transarterial chemoembolization
  16. Detection and characterization of circulating tumor associated cells in metastatic breast cancer
  17. Prospective changes in global DNA methylation and cancer incidence and mortality
  18. Effects of Cancer Stage and Treatment Differences on Racial Disparities in Survival from Colon Cancer: A United States Population-Based Study
  19. Cell-free circulating mitochondrial DNA content and risk of hepatocellular carcinoma in patients with chronic HBV infection
  20. The doylestown algorithm: A test to improve the performance of afp in the detection of hepatocellular carcinoma