Xiaohua Niu, Ting Zhang, Lili Liao, Liang Zhou, Ming Zhou, Daniel J. Lindner, Brian Rini, Qin Yan, Haifeng Yang. 2011. The von Hippel-Lindau Tumor Suppressor Protein Regulates Gene Expression and Tumorigenesis through Histone Demethylase JARID1C. 2012. Oncogene. 31(6):776-86.
This paper explained that activated HIF, as a result of VHL loss, caused the activation of a histone demethylase, JARID1C. In turn JARID1C changed transcription and repressed tumor growth, constituting a negative feedback loop. This provided the pressure to mutate JARID1C in kidney cancer.
Liang Zhou, Haifeng Yang. 2011. The von Hippel-Lindau Tumor Suppressor Protein Promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR. 2011. PLoS One. 6(9):e23936.
This article discovered that pVHL could target the activated EGFR for degration. This suggested that in VHL-defective cells EGFR is more activated and contributed to enhanced tumor growth.
Ting Zhang, Xiaohua Niu, Lili Liao, Eun-Ah Cho, Haifeng Yang. 2013. The Contributions of HIF-target Genes to Tumor Growth in RCC. PLoS One. 8(11):e80544.
This paper revealed that some HIF-target genes are not tumor-promoting. Instead they had anti-tumor effects. This suggested that enhancing the expression of some HIF-target genes could be a way to treat kidney cancer.